Prosaposin is a regulator of progranulin levels and oligomerization
Prosaposin is a regulator of progranulin levels and oligomerization
About this item
Full title
Author / Creator
Nicholson, Alexandra M. , Finch, NiCole A. , Almeida, Marcio , Perkerson, Ralph B. , van Blitterswijk, Marka , Wojtas, Aleksandra , Cenik, Basar , Rotondo, Sergio , Inskeep, Venette , Almasy, Laura , Dyer, Thomas , Peralta, Juan , Jun, Goo , Wood, Andrew R. , Frayling, Timothy M. , Fuchsberger, Christian , Fowler, Sharon , Teslovich, Tanya M. , Manning, Alisa K. , Kumar, Satish , Curran, Joanne , Lehman, Donna , Abecasis, Goncalo , Duggirala, Ravindranath , Pottier, Cyril , Zahir, Haaris A. , Crook, Julia E. , Karydas, Anna , Mitic, Laura , Sun, Ying , Dickson, Dennis W. , Bu, Guojun , Herz, Joachim , Yu, Gang , Miller, Bruce L. , Ferguson, Shawn , Petersen, Ronald C. , Graff-Radford, Neill , Blangero, John and Rademakers, Rosa
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Progranulin (
GRN
) loss-of-function mutations leading to progranulin protein (PGRN) haploinsufficiency are prevalent genetic causes of frontotemporal dementia. Reports also indicated PGRN-mediated neuroprotection in models of Alzheimer’s and Parkinson’s disease; thus, increasing PGRN levels is a promising therapeutic for multiple disorders....
Alternative Titles
Full title
Prosaposin is a regulator of progranulin levels and oligomerization
Authors, Artists and Contributors
Author / Creator
Finch, NiCole A.
Almeida, Marcio
Perkerson, Ralph B.
van Blitterswijk, Marka
Wojtas, Aleksandra
Cenik, Basar
Rotondo, Sergio
Inskeep, Venette
Almasy, Laura
Dyer, Thomas
Peralta, Juan
Jun, Goo
Wood, Andrew R.
Frayling, Timothy M.
Fuchsberger, Christian
Fowler, Sharon
Teslovich, Tanya M.
Manning, Alisa K.
Kumar, Satish
Curran, Joanne
Lehman, Donna
Abecasis, Goncalo
Duggirala, Ravindranath
Pottier, Cyril
Zahir, Haaris A.
Crook, Julia E.
Karydas, Anna
Mitic, Laura
Sun, Ying
Dickson, Dennis W.
Bu, Guojun
Herz, Joachim
Yu, Gang
Miller, Bruce L.
Ferguson, Shawn
Petersen, Ronald C.
Graff-Radford, Neill
Blangero, John
Rademakers, Rosa
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_69727bed9cd74c41b1fff7349a1c4efe
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_69727bed9cd74c41b1fff7349a1c4efe
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms11992
