Riluzole partially restores RNA polymerase III complex assembly in cells expressing the leukodystrop...
Riluzole partially restores RNA polymerase III complex assembly in cells expressing the leukodystrophy-causative variant POLR3B R103H
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Publisher
England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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The mechanism of assembly of RNA polymerase III (Pol III), the 17-subunit enzyme that synthesizes tRNAs, 5 S rRNA, and other small-nuclear (sn) RNAs in eukaryotes, is not clearly understood. The recent discovery of the HSP90 co-chaperone PAQosome (Particle for Arrangement of Quaternary structure) revealed a function for this machinery in the biogen...
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Full title
Riluzole partially restores RNA polymerase III complex assembly in cells expressing the leukodystrophy-causative variant POLR3B R103H
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TN_cdi_doaj_primary_oai_doaj_org_article_699d46ec64a246f1bf33569e5c276cc4
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_699d46ec64a246f1bf33569e5c276cc4
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ISSN
1756-6606
E-ISSN
1756-6606
DOI
10.1186/s13041-022-00974-z
