Normalization and variance stabilization of single-cell RNA-seq data using regularized negative bino...
Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression
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Publisher
England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Single-cell RNA-seq (scRNA-seq) data exhibits significant cell-to-cell variation due to technical factors, including the number of molecules detected in each cell, which can confound biological heterogeneity with technical effects. To address this, we present a modeling framework for the normalization and variance stabilization of molecular count d...
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Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression
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TN_cdi_doaj_primary_oai_doaj_org_article_6bb8ef5e3bc44c6e84eabcff715b74c3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6bb8ef5e3bc44c6e84eabcff715b74c3
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ISSN
1474-760X,1474-7596
E-ISSN
1474-760X
DOI
10.1186/s13059-019-1874-1
