Reversal of neuronal tau pathology via adiponectin receptor activation
Reversal of neuronal tau pathology via adiponectin receptor activation
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Changes in brain mitochondrial metabolism are coincident with functional decline; however, direct links between the two have not been established. Here, we show that mitochondrial targeting via the adiponectin receptor activator AdipoRon (AR) clears neurofibrillary tangles (NFTs) and rescues neuronal tauopathy-associated defects. AR reduced levels...
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Reversal of neuronal tau pathology via adiponectin receptor activation
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TN_cdi_doaj_primary_oai_doaj_org_article_6bec160dd47245bc8d6f9e2f71d9f481
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6bec160dd47245bc8d6f9e2f71d9f481
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ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-024-07391-z
