Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of pro...
Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variants
About this item
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Author / Creator
Garnsey, Michelle R. , Wang, Yang , Edmonds, David J. , Sammons, Matthew F. , Reidich, Benjamin , Ahn, Youngwook , Ashkenazi, Yotam , Carlo, Anthony , Cerny, Matthew A. , Coffman, Karen J. , Culver, Jeffrey A. , Dechert Schmitt, Anne-Marie , Eng, Heather , Fisher, Ethan L. , Gutierrez, Jemy A. , James, Larry , Jordan, Samantha , Kohrt, Jeffrey T. , Kramer, Melissa , LaChapelle, Erik A. , Lee, Jack C. , Lee, Jisun , Li, Dongmei , Li, Zhenhong , Liu, Shenping , Liu, Jianhua , Magee, Thomas V. , Miller, Melissa R. , Moran, Michael , Nason, Deane M. , Nedoma, Nicole L. , O’Neil, Steven V. , Piotrowski, Mary A. , Racich, Jillian , Sommese, Ruth F. , Stevens, Lucy M. , Wright, Ann S. , Xiao, Jun , Zhang, Liying , Zhou, Dahui , Barrandon, Ornella and Clasquin, Michelle F.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Several hydroxysteroid dehydrogenase 17-beta 13 variants have previously been identified as protective against metabolic dysfunction-associated steatohepatitis (MASH) fibrosis, ballooning and inflammation, and as such this target holds significant therapeutic potential. However, over 5 years later, the function of 17B-HSD13 remains unknown. Structu...
Alternative Titles
Full title
Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variants
Authors, Artists and Contributors
Author / Creator
Wang, Yang
Edmonds, David J.
Sammons, Matthew F.
Reidich, Benjamin
Ahn, Youngwook
Ashkenazi, Yotam
Carlo, Anthony
Cerny, Matthew A.
Coffman, Karen J.
Culver, Jeffrey A.
Dechert Schmitt, Anne-Marie
Eng, Heather
Fisher, Ethan L.
Gutierrez, Jemy A.
James, Larry
Jordan, Samantha
Kohrt, Jeffrey T.
Kramer, Melissa
LaChapelle, Erik A.
Lee, Jack C.
Lee, Jisun
Li, Dongmei
Li, Zhenhong
Liu, Shenping
Liu, Jianhua
Magee, Thomas V.
Miller, Melissa R.
Moran, Michael
Nason, Deane M.
Nedoma, Nicole L.
O’Neil, Steven V.
Piotrowski, Mary A.
Racich, Jillian
Sommese, Ruth F.
Stevens, Lucy M.
Wright, Ann S.
Xiao, Jun
Zhang, Liying
Zhou, Dahui
Barrandon, Ornella
Clasquin, Michelle F.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_6c4e53ca0d4f4ff0a1accd310f25ebee
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6c4e53ca0d4f4ff0a1accd310f25ebee
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-54487-5
