In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural produ...
In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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One major bottleneck in natural product drug development is derivatization, which is pivotal for fine tuning lead compounds. A promising solution is modifying the biosynthetic machineries of middle molecules such as macrolides. Although intense studies have established various methodologies for protein engineering of type I modular polyketide synth...
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In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives
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TN_cdi_doaj_primary_oai_doaj_org_article_6d001e0fbfd74c5b9143e6e06438d202
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6d001e0fbfd74c5b9143e6e06438d202
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-17769-2
