A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly ov...
A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways
About this item
Full title
Author / Creator
Piragyte, Indre , Clapes, Thomas , Polyzou, Aikaterini , Klein Geltink, Ramon I. , Lefkopoulos, Stylianos , Yin, Na , Cauchy, Pierre , Curtis, Jonathan D. , Klaeylé, Lhéanna , Langa, Xavier , Beckmann, Cora C. A. , Wlodarski, Marcin W. , Müller, Patrick , Van Essen, Dominic , Rambold, Angelika , Kapp, Friedrich G. , Mione, Marina , Buescher, Joerg M. , Pearce, Erika L. , Polyzos, Alexander and Trompouki, Eirini
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The H2.0-like homeobox transcription factor (HLX) regulates hematopoietic differentiation and is overexpressed in Acute Myeloid Leukemia (AML), but the mechanisms underlying these functions remain unclear. We demonstrate here that HLX overexpression leads to a myeloid differentiation block both in zebrafish and human hematopoietic stem and progenit...
Alternative Titles
Full title
A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways
Authors, Artists and Contributors
Author / Creator
Clapes, Thomas
Polyzou, Aikaterini
Klein Geltink, Ramon I.
Lefkopoulos, Stylianos
Yin, Na
Cauchy, Pierre
Curtis, Jonathan D.
Klaeylé, Lhéanna
Langa, Xavier
Beckmann, Cora C. A.
Wlodarski, Marcin W.
Müller, Patrick
Van Essen, Dominic
Rambold, Angelika
Kapp, Friedrich G.
Mione, Marina
Buescher, Joerg M.
Pearce, Erika L.
Polyzos, Alexander
Trompouki, Eirini
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_6e1870de09fa401dacacea3d50a2697e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6e1870de09fa401dacacea3d50a2697e
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05311-4
