Molecular tuning of farnesoid X receptor partial agonism
Molecular tuning of farnesoid X receptor partial agonism
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
The bile acid-sensing transcription factor farnesoid X receptor (FXR) regulates multiple metabolic processes. Modulation of FXR is desired to overcome several metabolic pathologies but pharmacological administration of full FXR agonists has been plagued by mechanism-based side effects. We have developed a modulator that partially activates FXR in v...
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Molecular tuning of farnesoid X receptor partial agonism
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TN_cdi_doaj_primary_oai_doaj_org_article_6e7a5ba2682343c4b07e17fc173490a6
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6e7a5ba2682343c4b07e17fc173490a6
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-10853-2
