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ArticlesPeer ReviewedFull Text
Rapid isolation and enrichment of extracellular vesicle preparations using anion exchange chromatography
Author / Creator:Heath, Nikki ; Grant, Lois ; De Oliveira, Taiana Maia ; Rowlinson, Rachel ; Osteikoetxea, Xabier ; Dekker, Niek ; Overman, Ross
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2018-04, Vol.8 (1), p.5730-12, Article 5730
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Chemogenetics defines a short-chain fatty acid receptor gut-brain axis
Author / Creator:Barki, Natasja ; Bolognini, Daniele ; Börjesson, Ulf ; Jenkins, Laura ; Riddell, John ; Hughes, David I ; Ulven, Trond ; Hudson, Brian D ; Ulven, Elisabeth Rexen ; Dekker, Niek ; Tobin, Andrew B ; Milligan, Graeme
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2022-03, Vol.11
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Molecular tuning of farnesoid X receptor partial agonism
Author / Creator:Merk, Daniel ; Sreeramulu, Sridhar ; Kudlinzki, Denis ; Saxena, Krishna ; Linhard, Verena ; Gande, Santosh L. ; Hiller, Fabian ; Lamers, Christina ; Nilsson, Ewa ; Aagaard, Anna ; Wissler, Lisa ; Dekker, Niek ; Bamberg, Krister ; Schubert-Zsilavecz, Manfred ; Schwalbe, Harald
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-07, Vol.10 (1), p.2915-14, Article 2915
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Quantification of protein cargo loading into engineered extracellular vesicles at single‐vesicle and single‐molecule resolution
Author / Creator:Silva, Andreia M. ; Lázaro‐Ibáñez, Elisa ; Gunnarsson, Anders ; Dhande, Aditya ; Daaboul, George ; Peacock, Ben ; Osteikoetxea, Xabier ; Salmond, Nikki ; Friis, Kristina Pagh ; Shatnyeva, Olga ; Dekker, Niek
Publisher:United States: John Wiley & Sons, Inc
Journal title:Journal of extracellular vesicles, 2021-08, Vol.10 (10), p.e12130-n/a
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In vivo phage display identifies novel peptides for cardiac targeting
Author / Creator:Ivanova, Alena ; Kohl, Franziska ; González-King Garibotti, Hernán ; Chalupska, Renata ; Cvjetkovic, Aleksander ; Firth, Mike ; Jennbacken, Karin ; Martinsson, Sofia ; Silva, Andreia M. ; Viken, Ida ; Wang, Qing-Dong ; Wiseman, John ; Dekker, Niek
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2024-05, Vol.14 (1), p.12177-12177, Article 12177
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Engineered Cas9 extracellular vesicles as a novel gene editing tool
Author / Creator:Osteikoetxea, Xabier ; Silva, Andreia ; Lázaro‐Ibáñez, Elisa ; Salmond, Nikki ; Shatnyeva, Olga ; Stein, Josia ; Schick, Jan ; Wren, Stephen ; Lindgren, Julia ; Firth, Mike ; Madsen, Alexandra ; Mayr, Lorenz M. ; Overman, Ross ; Davies, Rick ; Dekker, Niek
Publisher:United States: John Wiley & Sons, Inc
Journal title:Journal of extracellular vesicles, 2022-05, Vol.11 (5), p.e12225-n/a
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Molecular architecture of potassium chloride co-transporter KCC2
Author / Creator:Agez, Morgane ; Schultz, Patrick ; Medina, Igor ; Baker, David J. ; Burnham, Matthew P. ; Cardarelli, Ross A. ; Conway, Leslie C. ; Garnier, Kelly ; Geschwindner, Stefan ; Gunnarsson, Anders ; McCall, Eileen J. ; Frechard, Alexandre ; Audebert, Stéphane ; Deeb, Tarek Z. ; Moss, Stephen J. ; Brandon, Nicholas J. ; Wang, Qi ; Dekker, Niek ; Jawhari, Anass
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-11, Vol.7 (1), p.16452-14, Article 16452
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Creating Designer Engineered Extracellular Vesicles for Diverse Ligand Display, Target Recognition, and Controlled Protein Loading and Delivery
Author / Creator:Ivanova, Alena ; Badertscher, Lukas ; O'Driscoll, Gwen ; Bergman, Joakim ; Gordon, Euan ; Gunnarsson, Anders ; Johansson, Camilla ; Munson, Michael J. ; Spinelli, Cristiana ; Torstensson, Sara ; Vilén, Liisa ; Voirel, Andrei ; Wiseman, John ; Rak, Janusz ; Dekker, Niek ; Lázaro‐Ibáñez, Elisa
Publisher:Germany: John Wiley & Sons, Inc
Journal title:Advanced science, 2023-12, Vol.10 (34), p.e2304389-n/a
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Human pancreatic islet-derived extracellular vesicles modulate insulin expression in 3D-differentiating iPSC clusters
Author / Creator:Ribeiro, Diana ; Andersson, Eva-Marie ; Heath, Nikki ; Persson-Kry, Anette ; Collins, Richard ; Hicks, Ryan ; Dekker, Niek ; Forslöw, Anna
Publisher:United States: Public Library of Science
Journal title:PloS one, 2017-11, Vol.12 (11), p.e0187665-e0187665
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Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition
Author / Creator:Kennedy, Amanda J. ; Sundström, Linda ; Geschwindner, Stefan ; Poon, Eunice K. Y. ; Jiang, Yuhong ; Chen, Rongfeng ; Cooke, Rob ; Johnstone, Shawn ; Madin, Andrew ; Lim, Junxian ; Liu, Qingqi ; Lohman, Rink-Jan ; Nordqvist, Anneli ; Fridén-Saxin, Maria ; Yang, Wenzhen ; Brown, Dean G. ; Fairlie, David P. ; Dekker, Niek
Publisher:London: Nature Publishing Group UK
Journal title:Communications biology, 2020-12, Vol.3 (1), p.782-782, Article 782
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Barcoded Hybrids of Extracellular Vesicles and Lipid Nanoparticles for Multiplexed Analysis of Tissue Distribution
Author / Creator:Ivanova, Alena ; Chalupska, Renata ; Louro, Ana Filipa ; Firth, Mike ; González‐King Garibotti, Hernán ; Hultin, Leif ; Kohl, Franziska ; Lázaro‐Ibáñez, Elisa ; Lindgren, Julia ; Musa, Gentian ; Oude Blenke, Erik ; Silva, Andreia M. ; Szeponik, Louis ; Taylor, Agnes ; Viken, Ida ; Wang, Xiaoqin ; Jennbacken, Karin ; Wiseman, John ; Dekker, Niek
Publisher:Germany: John Wiley & Sons, Inc
Journal title:Advanced science, 2025-03, Vol.12 (10), p.e2407850-n/a
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Head‐to‐head comparison of relevant cell sources of small extracellular vesicles for cardiac repair: Superiority of embryonic stem cells
Author / Creator:González‐King, Hernán ; Rodrigues, Patricia G. ; Albery, Tamsin ; Tangruksa, Benyapa ; Gurrapu, Ramya ; Silva, Andreia M. ; Musa, Gentian ; Kardasz, Dominika ; Liu, Kai ; Kull, Bengt ; Åvall, Karin ; Rydén‐Markinhuhta, Katarina ; Incitti, Tania ; Sharma, Nitin ; Graneli, Cecilia ; Valadi, Hadi ; Petkevicius, Kasparas ; Carracedo, Miguel ; Tejedor, Sandra ; Ivanova, Alena ; Heydarkhan‐Hagvall, Sepideh ; Menasché, Phillipe ; Synnergren, Jane ; Dekker, Niek ; Wang, Qing‐Dong ; Jennbacken, Karin
Publisher:United States: Taylor & Francis
Journal title:Journal of extracellular vesicles, 2024-05, Vol.13 (5), p.e12445-n/a
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Crystal structure of the outer membrane protease OmpT from Escherichia coli suggests a novel catalytic site
Author / Creator:Vandeputte-Rutten, Lucy ; Kramer, R.Arjen ; Kroon, Jan ; Dekker, Niek ; Egmond, Maarten R. ; Gros, Piet
Publisher:Chichester, UK: John Wiley & Sons, Ltd
Journal title:The EMBO journal, 2001-09, Vol.20 (18), p.5033-5039
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Structural insight into allosteric modulation of protease-activated receptor 2
Author / Creator:Cheng, Robert K. Y. ; Fiez-Vandal, Cédric ; Schlenker, Oliver ; Edman, Karl ; Aggeler, Birte ; Brown, Dean G. ; Brown, Giles A. ; Cooke, Robert M. ; Dumelin, Christoph E. ; Doré, Andrew S. ; Geschwindner, Stefan ; Grebner, Christoph ; Hermansson, Nils-Olov ; Jazayeri, Ali ; Johansson, Patrik ; Leong, Louis ; Prihandoko, Rudi ; Rappas, Mathieu ; Soutter, Holly ; Snijder, Arjan ; Sundström, Linda ; Tehan, Benjamin ; Thornton, Peter ; Troast, Dawn ; Wiggin, Giselle ; Zhukov, Andrei ; Marshall, Fiona H. ; Dekker, Niek
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-05, Vol.545 (7652), p.112-115
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Solution structure of the POU-specific DNA-binding domain of Oct-1
Author / Creator:Dekker, Niek ; Cox, Michel ; Boelens, Rolf ; Verrijzer, C. Peter ; van der Vliet, Peter C. ; Kaptein, Robert
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 1993-04, Vol.362 (6423), p.852-855
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G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent
Author / Creator:Jamshad, Mohammed ; Charlton, Jack ; Lin, Yu-Pin ; Routledge, Sarah J ; Bawa, Zharain ; Knowles, Timothy J ; Overduin, Michael ; Dekker, Niek ; Dafforn, Tim R ; Bill, Roslyn M ; Poyner, David R ; Wheatley, Mark
Publisher:England: Portland Press Ltd
Journal title:Bioscience reports, 2015-04, Vol.35 (2)
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Oncostatin M-Enriched Small Extracellular Vesicles Derived from Mesenchymal Stem Cells Prevent Isoproterenol-Induced Fibrosis and Enhance Angiogenesis
Author / Creator:Tejedor, Sandra ; Buigues, Marc ; González-King, Hernán ; Silva, Andreia M ; García, Nahuel Aquiles ; Dekker, Niek ; Sepúlveda, Pilar
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2023-03, Vol.24 (7), p.6467
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The small molecule CLP257 does not modify activity of the K + -Cl - co-transporter KCC2 but does potentiate GABA A receptor activity
Author / Creator:Cardarelli, Ross A ; Jones, Karen ; Pisella, Lucie I ; Wobst, Heike J ; McWilliams, Lisa J ; Sharpe, Paul M ; Burnham, Matthew P ; Baker, David J ; Chudotvorova, Ilona ; Guyot, Justine ; Silayeva, Liliya ; Morrow, Danielle H ; Dekker, Niek ; Zicha, Stephen ; Davies, Paul A ; Holenz, Jörg ; Duggan, Mark E ; Dunlop, John ; Mather, Robert J ; Wang, Qi ; Medina, Igor ; Brandon, Nicholas J ; Deeb, Tarek Z ; Moss, Stephen J
Publisher:United States
Journal title:Nature medicine, 2017-12, Vol.23 (12), p.1394
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ArticlesPeer ReviewedFull Text
Human pancreatic islet-derived extracellular vesicles modulates insulin expression in 3D-differentiating iPS clusters
Author / Creator:Ribeiro, Diana ; Andersson, Eva-Marie ; Heath, Nikki ; Persson-kry, Anette ; Collins, Richard ; Hicks, Ryan ; Dekker, Niek ; Forslöw, Anna
Journal title:PloS one, 2017, Vol.12 (11)
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Endosomal escape enhancing compounds facilitate functional delivery of extracellular vesicle cargo
Author / Creator:Heath, Nikki ; Osteikoetxea, Xabier ; de Oliveria, Taiana Mia ; Lázaro-Ibáñez, Elisa ; Shatnyeva, Olga ; Schindler, Christina ; Tigue, Natalie ; Mayr, Lorenz M ; Dekker, Niek ; Overman, Ross ; Davies, Rick
Publisher:England: Future Medicine Ltd
Journal title:Nanomedicine (London, England), 2019-11, Vol.14 (21), p.2799-2814
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Rapid isolation and enrichment of extracellular vesicle preparations using anion exchange chromatography

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Chemogenetics defines a short-chain fatty acid receptor gut-brain axis

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Molecular tuning of farnesoid X receptor partial agonism

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Quantification of protein cargo loading into engineered extracellular vesicles at single‐vesicle and single‐molecule resolution

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In vivo phage display identifies novel peptides for cardiac targeting

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Engineered Cas9 extracellular vesicles as a novel gene editing tool

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Molecular architecture of potassium chloride co-transporter KCC2

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Creating Designer Engineered Extracellular Vesicles for Diverse Ligand Display, Target Recognition, and Controlled Protein Loading and Delivery

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Human pancreatic islet-derived extracellular vesicles modulate insulin expression in 3D-differentiating iPSC clusters

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Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition

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Barcoded Hybrids of Extracellular Vesicles and Lipid Nanoparticles for Multiplexed Analysis of Tissue Distribution

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Head‐to‐head comparison of relevant cell sources of small extracellular vesicles for cardiac repair: Superiority of embryonic stem cells

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Crystal structure of the outer membrane protease OmpT from Escherichia coli suggests a novel catalytic site

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Structural insight into allosteric modulation of protease-activated receptor 2

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Solution structure of the POU-specific DNA-binding domain of Oct-1

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G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent

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Oncostatin M-Enriched Small Extracellular Vesicles Derived from Mesenchymal Stem Cells Prevent Isoproterenol-Induced Fibrosis and Enhance Angiogenesis

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The small molecule CLP257 does not modify activity of the K + -Cl - co-transporter KCC2 but does potentiate GABA A receptor activity

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Human pancreatic islet-derived extracellular vesicles modulates insulin expression in 3D-differentiating iPS clusters

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Endosomal escape enhancing compounds facilitate functional delivery of extracellular vesicle cargo

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