Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair
Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Repair of double strand DNA breaks (DSBs) can result in gene disruption or gene modification via homology directed repair (HDR) from donor DNA. Altering cellular responses to DSBs may rebalance editing outcomes towards HDR and away from other repair outcomes. Here, we utilize a pooled CRISPR screen to define host cell involvement in HDR between a C...
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Full title
Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair
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TN_cdi_doaj_primary_oai_doaj_org_article_6ea294e461964f21b3fa07be064041d4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6ea294e461964f21b3fa07be064041d4
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-15845-1
