Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine...
Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Ca
2+
entry via Ca
2+
release-activated Ca
2+
(CRAC) channels is a predominant mechanism of intracellular Ca
2+
elevation in immune cells. Here we show the immunoregulatory role of CRAC channel components Orai1 and Orai2 in Group 2 innate lymphoid cells (ILC2s), that play crucial roles in the induction of type 2 inflammation...
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Full title
Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models
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TN_cdi_doaj_primary_oai_doaj_org_article_6ea722380e2340a785089d7d327b7642
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6ea722380e2340a785089d7d327b7642
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-41065-4
