A mutational atlas for Parkin proteostasis
A mutational atlas for Parkin proteostasis
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Proteostasis can be disturbed by mutations affecting folding and stability of the encoded protein. An example is the ubiquitin ligase Parkin, where gene variants result in autosomal recessive Parkinsonism. To uncover the pathological mechanism and provide comprehensive genotype-phenotype information, variant abundance by massively parallel sequenci...
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Full title
A mutational atlas for Parkin proteostasis
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TN_cdi_doaj_primary_oai_doaj_org_article_6ff4219e4bce40eb81ed52752e8585a9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6ff4219e4bce40eb81ed52752e8585a9
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-45829-4
