Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse int...
Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model
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England: eLife Science Publications, Ltd
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Language
English
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Publisher
England: eLife Science Publications, Ltd
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Increasing evidence supports a role for deficient Wnt signaling in Alzheimer's disease (AD). Studies reveal that the secreted Wnt antagonist Dickkopf-3 (DKK3) colocalizes to amyloid plaques in AD patients. Here, we investigate the contribution of DKK3 to synapse integrity in healthy and AD brains. Our findings show that DKK3 expression is upregulat...
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Full title
Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model
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TN_cdi_doaj_primary_oai_doaj_org_article_7039ff22efa5466e8bf198b4a028d12c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7039ff22efa5466e8bf198b4a028d12c
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.89453
