An MPER antibody neutralizes HIV-1 using germline features shared among donors
An MPER antibody neutralizes HIV-1 using germline features shared among donors
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Author / Creator
IAVI Protocol G Investigators , SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States). Stanford Synchrotron Radiation Lightsource (SSRL) , Zhang, Lei , Irimia, Adriana , He, Lingling , Landais, Elise , Rantalainen, Kimmo , Leaman, Daniel P. , Vollbrecht, Thomas , Stano, Armando , Sands, Daniel I. , Kim, Arthur S. , Poignard, Pascal , Burton, Dennis R. , Murrell, Ben , Ward, Andrew B. , Zhu, Jiang , Wilson, Ian A. and Zwick, Michael B.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The membrane-proximal external region (MPER) of HIV-1 envelope glycoprotein (Env) can be targeted by neutralizing antibodies of exceptional breadth. MPER antibodies usually have long, hydrophobic CDRH3s, lack activity as inferred germline precursors, are often from the minor IgG3 subclass, and some are polyreactive, such as 4E10. Here we describe a...
Alternative Titles
Full title
An MPER antibody neutralizes HIV-1 using germline features shared among donors
Authors, Artists and Contributors
Author / Creator
SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States). Stanford Synchrotron Radiation Lightsource (SSRL)
Zhang, Lei
Irimia, Adriana
He, Lingling
Landais, Elise
Rantalainen, Kimmo
Leaman, Daniel P.
Vollbrecht, Thomas
Stano, Armando
Sands, Daniel I.
Kim, Arthur S.
Poignard, Pascal
Burton, Dennis R.
Murrell, Ben
Ward, Andrew B.
Zhu, Jiang
Wilson, Ian A.
Zwick, Michael B.
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_706277bc9dfa4fb4814343163603b088
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_706277bc9dfa4fb4814343163603b088
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-12973-1
