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An MPER antibody neutralizes HIV-1 using germline features shared among donors

An MPER antibody neutralizes HIV-1 using germline features shared among donors

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_706277bc9dfa4fb4814343163603b088

An MPER antibody neutralizes HIV-1 using germline features shared among donors

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Publication information

Publisher

London: Nature Publishing Group UK

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Scope and Contents

Contents

The membrane-proximal external region (MPER) of HIV-1 envelope glycoprotein (Env) can be targeted by neutralizing antibodies of exceptional breadth. MPER antibodies usually have long, hydrophobic CDRH3s, lack activity as inferred germline precursors, are often from the minor IgG3 subclass, and some are polyreactive, such as 4E10. Here we describe a...

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Full title

An MPER antibody neutralizes HIV-1 using germline features shared among donors

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Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_706277bc9dfa4fb4814343163603b088

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_706277bc9dfa4fb4814343163603b088

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-019-12973-1