Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule
Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Molecules that alter the normal dynamics of microtubule assembly and disassembly include many anticancer drugs in clinical use. So far all such therapeutics target β-tubulin, and structural biology has explained the basis of their action and permitted design of new drugs. However, by shifting the profile of β-tubulin isoforms, cancer cells become r...
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Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule
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TN_cdi_doaj_primary_oai_doaj_org_article_706d09f37b2b4e7daab3ae36d7438e61
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_706d09f37b2b4e7daab3ae36d7438e61
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms12103
