Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated si...
Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice
About this item
Full title
Author / Creator
Driscoll, Rachelle , Hampton, Lucas , Abraham, Neeta A. , Larigan, J. Douglas , Joseph, Nadine F. , Hernandez-Vega, Juan C. , Geisler, Sarah , Yang, Fu-Chia , Deninger, Matthew , Tran, David T. , Khatri, Natasha , Godinho, Bruno M. D. C. , Kinberger, Garth A. , Montagna, Daniel R. , Hirst, Warren D. , Guardado, Catherine L. , Glajch, Kelly E. , Arnold, H. Moore , Gallant-Behm, Corrie L. and Weihofen, Andreas
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by CAG trinucleotide repeat expansions in exon 1 of the
HTT
gene. In addition to germline CAG expansions, somatic repeat expansions in neurons also contribute to HD pathogenesis. The DNA mismatch repair gene, MSH3, identified as a genetic modifier of HD onset and pro...
Alternative Titles
Full title
Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice
Authors, Artists and Contributors
Author / Creator
Hampton, Lucas
Abraham, Neeta A.
Larigan, J. Douglas
Joseph, Nadine F.
Hernandez-Vega, Juan C.
Geisler, Sarah
Yang, Fu-Chia
Deninger, Matthew
Tran, David T.
Khatri, Natasha
Godinho, Bruno M. D. C.
Kinberger, Garth A.
Montagna, Daniel R.
Hirst, Warren D.
Guardado, Catherine L.
Glajch, Kelly E.
Arnold, H. Moore
Gallant-Behm, Corrie L.
Weihofen, Andreas
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_708fdef928c448a8ad36da3b5a637de6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_708fdef928c448a8ad36da3b5a637de6
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-024-52667-3
