miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy...
miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Functional depletion of the alternative splicing factors Muscleblind-like (MBNL 1 and 2) is at the basis of the neuromuscular disease myotonic dystrophy type 1 (DM1). We previously showed the efficacy of miRNA downregulation in
Drosophila
DM1 model. Here, we screen for miRNAs that regulate
MBNL1
and
MBNL2
in HeLa cells. We thus i...
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miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models
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TN_cdi_doaj_primary_oai_doaj_org_article_715ef215d4ed408da2bed0dd25f82d03
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_715ef215d4ed408da2bed0dd25f82d03
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04892-4
