Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug desi...
Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design
About this item
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Author / Creator
Funk, Lisa-Marie , Poschmann, Gereon , Rabe von Pappenheim, Fabian , Chari, Ashwin , Stegmann, Kim M. , Dickmanns, Antje , Wensien, Marie , Eulig, Nora , Paknia, Elham , Heyne, Gabi , Penka, Elke , Pearson, Arwen R. , Berndt, Carsten , Fritz, Tobias , Bazzi, Sophia , Uranga, Jon , Mata, Ricardo A. , Dobbelstein, Matthias , Hilgenfeld, Rolf , Curth, Ute and Tittmann, Kai
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
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Contents
Besides vaccines, the development of antiviral drugs targeting SARS-CoV-2 is critical for preventing future COVID outbreaks. The SARS-CoV-2 main protease (M
pro
), a cysteine protease with essential functions in viral replication, has been validated as an effective drug target. Here, we show that M
pro
is subject to redox regulation in...
Alternative Titles
Full title
Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design
Authors, Artists and Contributors
Author / Creator
Poschmann, Gereon
Rabe von Pappenheim, Fabian
Chari, Ashwin
Stegmann, Kim M.
Dickmanns, Antje
Wensien, Marie
Eulig, Nora
Paknia, Elham
Heyne, Gabi
Penka, Elke
Pearson, Arwen R.
Berndt, Carsten
Fritz, Tobias
Bazzi, Sophia
Uranga, Jon
Mata, Ricardo A.
Dobbelstein, Matthias
Hilgenfeld, Rolf
Curth, Ute
Tittmann, Kai
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_721e5465cdfb4b73a39d8f7ff2da8167
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_721e5465cdfb4b73a39d8f7ff2da8167
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-44621-0
