An improved SNAP-ADAR tool enables efficient RNA base editing to interfere with post-translational p...
An improved SNAP-ADAR tool enables efficient RNA base editing to interfere with post-translational protein modification
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Author / Creator
Kiran Kumar, Karthika Devi , Singh, Shubhangi , Schmelzle, Stella Maria , Vogel, Paul , Fruhner, Carolin , Hanswillemenke, Alfred , Brun, Adrian , Wettengel, Jacqueline , Füll, Yvonne , Funk, Lukas , Mast, Valentin , Botsch, J. Josephine , Reautschnig, Philipp , Li, Jin Billy and Stafforst, Thorsten
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
RNA base editing relies on the introduction of adenosine-to-inosine changes into target RNAs in a highly programmable manner in order to repair disease-causing mutations. Here, we propose that RNA base editing could be broadly applied to perturb protein function by removal of regulatory phosphorylation and acetylation sites. We demonstrate the feas...
Alternative Titles
Full title
An improved SNAP-ADAR tool enables efficient RNA base editing to interfere with post-translational protein modification
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_724df14e1cb54fe4a6a260b6d4615676
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_724df14e1cb54fe4a6a260b6d4615676
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-50395-w
