Chemical genomics reveals histone deacetylases are required for core regulatory transcription
Chemical genomics reveals histone deacetylases are required for core regulatory transcription
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Identity determining transcription factors (TFs), or core regulatory (CR) TFs, are governed by cell-type specific super enhancers (SEs). Drugs to selectively inhibit CR circuitry are of high interest for cancer treatment. In alveolar rhabdomyosarcoma, PAX3-FOXO1 activates SEs to induce the expression of other CR TFs, providing a model system for st...
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Chemical genomics reveals histone deacetylases are required for core regulatory transcription
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TN_cdi_doaj_primary_oai_doaj_org_article_742c055d88f34a9a94fff834255a1649
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_742c055d88f34a9a94fff834255a1649
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11046-7
