Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico
Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The creation of artificial enzymes is a key objective of computational protein design. Although de novo enzymes have been successfully designed, these exhibit low catalytic efficiencies, requiring directed evolution to improve activity. Here, we use room-temperature X-ray crystallography to study changes in the conformational ensemble during evolut...
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Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico
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TN_cdi_doaj_primary_oai_doaj_org_article_7439f4de0efc41d198a2176b909a8ff0
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7439f4de0efc41d198a2176b909a8ff0
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-18619-x
