Therapeutic potential of targeting the IRF2/POSTN/Notch1 axis in nucleus pulposus cells for interver...
Therapeutic potential of targeting the IRF2/POSTN/Notch1 axis in nucleus pulposus cells for intervertebral disc degeneration
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Intervertebral disc degeneration (IDD) is a leading cause of low back pain, often linked to inflammation and pyroptosis in nucleus pulposus (NP) cells. The role of Periostin (POSTN) in IDD remains unclear.
This study aims to investigate the influence of POSTN on pyroptosis and NLRP3 inflammasome activation in NP cells during IDD.
IVD samples...
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Full title
Therapeutic potential of targeting the IRF2/POSTN/Notch1 axis in nucleus pulposus cells for intervertebral disc degeneration
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TN_cdi_doaj_primary_oai_doaj_org_article_74eab9f37778499daecaeee4bb81febe
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_74eab9f37778499daecaeee4bb81febe
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ISSN
1742-2094
E-ISSN
1742-2094
DOI
10.1186/s12974-025-03335-4
