Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening
Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening
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England: eLife Science Publications, Ltd
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Language
English
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Publisher
England: eLife Science Publications, Ltd
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Colorectal cancer (CRC) organoids can be derived from almost all CRC patients and therefore capture the genetic diversity of this disease. We assembled a panel of CRC organoids carrying either wild-type or mutant RAS, as well as normal organoids and tumor organoids with a CRISPR-introduced oncogenic
mutation. Using this panel, we evaluated RAS p...
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Full title
Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening
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TN_cdi_doaj_primary_oai_doaj_org_article_7501d8e3fc1b4a42aa7676d2bb0a2f09
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7501d8e3fc1b4a42aa7676d2bb0a2f09
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.18489
