AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olapari...
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity
About this item
Full title
Author / Creator
Fok, Jacqueline H. L. , Ramos-Montoya, Antonio , Vazquez-Chantada, Mercedes , Wijnhoven, Paul W. G. , Follia, Valeria , James, Neil , Farrington, Paul M. , Karmokar, Ankur , Willis, Sophie E. , Cairns, Jonathan , Nikkilä, Jenni , Beattie, David , Lamont, Gillian M. , Finlay, M. Raymond V. , Wilson, Joanne , Smith, Aaron , O’Connor, Lenka Oplustil , Ling, Stephanie , Fawell, Stephen E. , O’Connor, Mark J. , Hollingsworth, Simon J. , Dean, Emma , Goldberg, Frederick W. , Davies, Barry R. and Cadogan, Elaine B.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
DNA-dependent protein kinase (DNA-PK) is a critical player in the DNA damage response (DDR) and instrumental in the non-homologous end-joining pathway (NHEJ) used to detect and repair DNA double-strand breaks (DSBs). We demonstrate that the potent and highly selective DNA-PK inhibitor, AZD7648, is an efficient sensitizer of radiation- and doxorubic...
Alternative Titles
Full title
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity
Authors, Artists and Contributors
Author / Creator
Ramos-Montoya, Antonio
Vazquez-Chantada, Mercedes
Wijnhoven, Paul W. G.
Follia, Valeria
James, Neil
Farrington, Paul M.
Karmokar, Ankur
Willis, Sophie E.
Cairns, Jonathan
Nikkilä, Jenni
Beattie, David
Lamont, Gillian M.
Finlay, M. Raymond V.
Wilson, Joanne
Smith, Aaron
O’Connor, Lenka Oplustil
Ling, Stephanie
Fawell, Stephen E.
O’Connor, Mark J.
Hollingsworth, Simon J.
Dean, Emma
Goldberg, Frederick W.
Davies, Barry R.
Cadogan, Elaine B.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7547983126794fc0a17cf1c4d462a298
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7547983126794fc0a17cf1c4d462a298
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-12836-9
