Log in to save to my catalogue

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olapari...

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olapari...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7547983126794fc0a17cf1c4d462a298

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

About this item

Full title

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2019-11, Vol.10 (1), p.5065-15, Article 5065

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

DNA-dependent protein kinase (DNA-PK) is a critical player in the DNA damage response (DDR) and instrumental in the non-homologous end-joining pathway (NHEJ) used to detect and repair DNA double-strand breaks (DSBs). We demonstrate that the potent and highly selective DNA-PK inhibitor, AZD7648, is an efficient sensitizer of radiation- and doxorubic...

Alternative Titles

Full title

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_7547983126794fc0a17cf1c4d462a298

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7547983126794fc0a17cf1c4d462a298

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-019-12836-9

How to access this item