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Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells

Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_762942600f0844a6ad8f1db2cc791d1d

Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells

About this item

Full title

Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2024-11, Vol.15 (1), p.10159-17, Article 10159

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Non-homologous end joining (NHEJ) is the predominant pathway that repairs DNA double-stranded breaks (DSBs) in vertebrates. However, due to challenges in detecting DSBs in living cells, the repair capacity of the NHEJ pathway is unknown. The DNA termini of many DSBs must be processed to allow ligation while minimizing genetic changes that result fr...

Alternative Titles

Full title

Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_762942600f0844a6ad8f1db2cc791d1d

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_762942600f0844a6ad8f1db2cc791d1d

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-024-54545-y

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