Exploratory window‐of‐opportunity trial to investigate the tumor pharmacokinetics/pharmacodynamics o...
Exploratory window‐of‐opportunity trial to investigate the tumor pharmacokinetics/pharmacodynamics of the IAP antagonist Debio 1143 in patients with head and neck cancer
About this item
Full title
Author / Creator
Gomez‐Roca, Carlos , Even, Caroline , Le Tourneau, Christophe , Basté, Neus , Delord, Jean‐Pierre , Sarini, Jerome , Vergez, Sebastien , Temam, Stephane , Hoffmann, Caroline , Rochaix, Philippe , Borcoman, Edith , Gavillet, Bruno , Rouits, Elisabeth , Ménétrey, Annick , Brichory, Franck , Purcea, Daniela , Vuagniaux, Gregoire and Zanna, Claudio
Publisher
United States: John Wiley & Sons, Inc
Journal title
Language
English
Formats
Publication information
Publisher
United States: John Wiley & Sons, Inc
Subjects
More information
Scope and Contents
Contents
Inhibitor of apoptosis proteins (IAPs) regulate apoptosis and modulate NF‐κB signaling thereby driving expression of genes involved in immune/inflammatory responses. The orally available IAP antagonist Debio 1143 has potential to enhance tumor response to chemoradiotherapy and/or immunotherapy. Patients with pre‐operative squamous cell carcinomas o...
Alternative Titles
Full title
Exploratory window‐of‐opportunity trial to investigate the tumor pharmacokinetics/pharmacodynamics of the IAP antagonist Debio 1143 in patients with head and neck cancer
Authors, Artists and Contributors
Author / Creator
Even, Caroline
Le Tourneau, Christophe
Basté, Neus
Delord, Jean‐Pierre
Sarini, Jerome
Vergez, Sebastien
Temam, Stephane
Hoffmann, Caroline
Rochaix, Philippe
Borcoman, Edith
Gavillet, Bruno
Rouits, Elisabeth
Ménétrey, Annick
Brichory, Franck
Purcea, Daniela
Vuagniaux, Gregoire
Zanna, Claudio
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_763c3b10898c4d3aa67f4e95f05892c4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_763c3b10898c4d3aa67f4e95f05892c4
Other Identifiers
ISSN
1752-8054
E-ISSN
1752-8062
DOI
10.1111/cts.13002
