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Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 tr...
Author / Creator:Le Tourneau, Christophe, Dr ; Delord, Jean-Pierre, Prof ; Gonçalves, Anthony, Prof ; Gavoille, Céline, MD ; Dubot, Coraline, MD ; Isambert, Nicolas, MD ; Campone, Mario, Prof ; Trédan, Olivier, MD ; Massiani, Marie-Ange, MD ; Mauborgne, Cécile, MSc ; Armanet, Sebastien, MSc ; Servant, Nicolas, PhD ; Bièche, Ivan, PhD ; Bernard, Virginie, PhD ; Gentien, David, PhD ; Jezequel, Pascal, MD ; Attignon, Valéry, PhD ; Boyault, Sandrine, PhD ; Vincent-Salomon, Anne, MD ; Servois, Vincent, MD ; Sablin, Marie-Paule, MD ; Kamal, Maud, PhD ; Paoletti, Xavier, PhD
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2015-10, Vol.16 (13), p.1324-1334
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Pembrolizumab in cervical cancer: latest evidence and clinical usefulness
Author / Creator:Borcoman, Edith ; Le Tourneau, Christophe
Publisher:London, England: SAGE Publications
Journal title:Therapeutic advances in medical oncology, 2017-06, Vol.9 (6), p.431-439
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Comparing programmed death ligand 1 scores for predicting pembrolizumab efficacy in head and neck cancer
Author / Creator:Emancipator, Kenneth ; Huang, Lingkang ; Aurora-Garg, Deepti ; Bal, Tricia ; Cohen, Ezra E.W. ; Harrington, Kevin ; Soulières, Denis ; Le Tourneau, Christophe ; Licitra, Lisa ; Burtness, Barbara ; Swaby, Ramona
Publisher:New York: Elsevier Inc
Journal title:Modern pathology, 2021-03, Vol.34 (3), p.532-541
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Prognostic value of intratumoral Fusobacterium nucleatum and association with immune-related gene expression in oral squamous cell carcinoma patients
Author / Creator:Neuzillet, Cindy ; Marchais, Manon ; Vacher, Sophie ; Hilmi, Marc ; Schnitzler, Anne ; Meseure, Didier ; Leclere, Renaud ; Lecerf, Charlotte ; Dubot, Coraline ; Jeannot, Emmanuelle ; Klijanienko, Jerzy ; Mariani, Odette ; Calugaru, Valentin ; Hoffmann, Caroline ; Lesnik, Maria ; Badois, Nathalie ; Borcoman, Edith ; Piaggio, Eliane ; Kamal, Maud ; Le Tourneau, Christophe ; Bieche, Ivan
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2021-04, Vol.11 (1), p.7870-13, Article 7870
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PD-L1 and ICOSL discriminate human Secretory and Helper dendritic cells in cancer, allergy and autoimmunity
Author / Creator:Hoffmann, Caroline ; Noel, Floriane ; Grandclaudon, Maximilien ; Massenet-Regad, Lucile ; Michea, Paula ; Sirven, Philemon ; Faucheux, Lilith ; Surun, Aurore ; Lantz, Olivier ; Bohec, Mylene ; Ye, Jian ; Guo, Weihua ; Rochefort, Juliette ; Klijanienko, Jerzy ; Baulande, Sylvain ; Lecerf, Charlotte ; Kamal, Maud ; Le Tourneau, Christophe ; Guillot-Delost, Maude ; Soumelis, Vassili
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-04, Vol.13 (1), p.1983-20, Article 1983
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Assessment of endpoint definitions in recurrent and metastatic mucosal head and neck squamous cell carcinoma trials: Head and Neck Cancer International Group consensus recommendations
Author / Creator:Lim, Annette M, PhD ; Le Tourneau, Christophe, Prof ; Hurt, Chris, MSc ; Laskar, Sarbani G, Prof ; Steuer, Conor E, MD ; Chow, Velda L Y, FCSHK ; Szturz, Petr, PhD ; Henson, Christina, MD ; Day, Andrew T, MD ; Bates, James E, MD ; Lazarakis, Smaro, BEd[Sec]-Lib ; McDowell, Lachlan, FRANZCR ; Mehanna, Hisham, Prof ; Yom, Sue S, Prof
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2024-07, Vol.25 (7), p.e308-e317
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Assessment of endpoint definitions in curative-intent trials for mucosal head and neck squamous cell carcinomas: Head and Neck Cancer International Group consensus recommendations
Author / Creator:Lim, Annette M, PhD ; McDowell, Lachlan, FRANZCR ; Hurt, Chris, MSc ; Le Tourneau, Christophe, Prof ; Homma, Akihiro, PhD ; Shenouda, George, FRCP ; Thomson, David J, Prof ; Moya-Plana, Antoine, Prof ; Henson, Christina, MD ; Szturz, Petr, PhD ; Day, Andrew T, MD ; Bates, James E, MD ; Lazarakis, Smaro, BEd[Sec]-Lib ; Thariat, Juliette, Prof ; Psyrri, Amanda, Prof ; Mehanna, Hisham, Prof ; Yom, Sue S, Prof
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2024-07, Vol.25 (7), p.e318-e330
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Ramucirumab in Combination with Pembrolizumab in Treatment-Naïve Advanced Gastric or GEJ Adenocarcinoma: Safety and Antitumor Activity from the Phase 1a/b JVDF Trial
Author / Creator:Chau, Ian ; Penel, Nicolas ; Soriano, Andres O. ; Arkenau, Hendrik-Tobias ; Cultrera, Jennifer ; Santana-Davila, Rafael ; Calvo, Emiliano ; Le Tourneau, Christophe ; Zender, Lars ; Bendell, Johanna C. ; Mi, Gu ; Gao, Ling ; McNeely, Samuel Clark ; Oliveira, Joana M. ; Ferry, David ; Herbst, Roy S. ; Fuchs, Charles S.
Publisher:Basel: MDPI AG
Journal title:Cancers, 2020-10, Vol.12 (10), p.2985
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ArticlesPeer ReviewedFull Text
Clinical Development of Molecular Targeted Therapy in Head and Neck Squamous Cell Carcinoma
Author / Creator:Gougis, Paul ; Moreau Bachelard, Camille ; Kamal, Maud ; Gan, Hui K ; Borcoman, Edith ; Torossian, Nouritza ; Bièche, Ivan ; Le Tourneau, Christophe
Publisher:England: Oxford University Press
Journal title:JNCI cancer spectrum, 2019-12, Vol.3 (4), p.pkz055
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A transcriptomics approach to expand therapeutic options and optimize clinical trials in oncology
Author / Creator:Lazar, Vladimir ; Zhang, Baolin ; Magidi, Shai ; Le Tourneau, Christophe ; Raymond, Eric ; Ducreux, Michel ; Bresson, Catherine ; Raynaud, Jacques ; Wunder, Fanny ; Onn, Amir ; Felip, Enriqueta ; Tabernero, Josep ; Batist, Gerald ; Kurzrock, Razelle ; Rubin, Eitan ; Schilsky, Richard L.
Publisher:London, England: SAGE Publications
Journal title:Therapeutic advances in medical oncology, 2023-01, Vol.15, p.17588359231156382
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Hyperprogression under Immunotherapy
Author / Creator:Frelaut, Maxime ; Le Tourneau, Christophe ; Borcoman, Edith
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2019-05, Vol.20 (11), p.2674
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A computational method for prioritizing targeted therapies in precision oncology: performance analysis in the SHIVA01 trial
Author / Creator:Petak, Istvan ; Kamal, Maud ; Dirner, Anna ; Bieche, Ivan ; Doczi, Robert ; Mariani, Odette ; Filotas, Peter ; Salomon, Anne ; Vodicska, Barbara ; Servois, Vincent ; Varkondi, Edit ; Gentien, David ; Tihanyi, Dora ; Tresca, Patricia ; Lakatos, Dora ; Servant, Nicolas ; Deri, Julia ; du Rusquec, Pauline ; Hegedus, Csilla ; Bello Roufai, Diana ; Schwab, Richard ; Dupain, Celia ; Valyi-Nagy, Istvan T. ; Le Tourneau, Christophe
Publisher:London: Nature Publishing Group UK
Journal title:NPJ precision oncology, 2021-06, Vol.5 (1), p.59-11, Article 59
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Molecular profiling in precision medicine oncology
Author / Creator:Le Tourneau, Christophe ; Borcoman, Edith ; Kamal, Maud
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2019-05, Vol.25 (5), p.711-712
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Erdafitinib in patients with advanced solid tumours with FGFR alterations (RAGNAR): an international, single-arm, phase 2 study
Author / Creator:Pant, Shubham ; Schuler, Martin ; Witt, Olaf ; Doi, Toshihiko ; Qin, Shukui ; Reardon, David A ; Massard, Christophe ; Minchom, Anna ; Lugowska, Iwona ; Carranza, Omar ; Arnold, Dirk ; Gutierrez, Martin ; Winter, Helen ; Stuyckens, Kim ; Najmi, Saltanat ; Hammond, Constance ; Santiago-Walker, Ademi ; Triantos, Spyros ; Sweiti, Hussein ; Greco, Martin Alberto ; Coward, Jim ; Joshua, Anthony ; Karapetis, Christos ; Hart, Christopher ; Zhang, Alison ; Prenen, Hans ; Rottey, Sylvie ; Molin, Graziela Zibetti Dal ; Tiscoski, Katsuki ; Jardim, Denis Leonardo Fontes ; Mak, Milena ; Fu, Wei ; Yao, Herui ; Huang, Jing ; Jiang, Haiping ; Yan, Dong ; Yang, Yu ; Le Tourneau, Christophe ; Penel, Nicolas ; Salas, Sébastien ; Blay, Jean-Yves ; Brachet, Pierre-Emmanuel ; Durando, Xavier ; Ravaud, Alain ; Folprecht, Gunnar ; Ahrens, Marit ; Golf, Alexander ; Haag, Georg Martin ; Desuki, Alexander ; Cazzaniga, Marina ; Ciardiello, Fortunato ; Milella, Michele ; Koyama, Takafumi ; Hirooka, Yoshiki ; Okamoto, Wataru ; Aogi, Kenjiro ; Kuboki, Yasutoshi ; Ahn, Myung-Ju ; Chang, Jong Hee ; Kim, Yong-Man ; Nam, Do-Hyun ; Park, Jae-Sung ; Moreno, Victor ; Cervantes, Andres ; Falcon, Alejandro ; Gonzalez, Antonio ; Martinez Bueno, Alejandro ; García-Corbacho, Javier ; Longo, Federico ; Yen, Chia-Jui ; Chen, Jen-Shi ; Hou, Ming-Feng ; Chao, Yee ; Rau, Kun-Ming ; Chiu, Tai-Jan ; Feng, Yin-Hsun ; Hsu, Chih-Hung ; Huang, Wen-Tsung ; Yeh, Su-peng ; Palmer, Daniel ; Welsh, Liam ; Plummer, Ruth ; Bilen, Mehmet ; Arrowsmith, Edward ; Spigel, David Robert ; Zandberg, Dan Paul ; Doroshow, Deborah ; Lu-Emerson, Christine ; Moezi, Mehdi ; Reardon, David ; Ward, Patrick ; Chaves, Jorge ; Grigg, Claud ; Hussein, Atif ; Manda, Sudhir ; Monticelli, Michael ; Qamar, Rubina ; Richey, Stephen L ; Tamura, David ; Wilks, Sharon
Publisher:Elsevier BV
Journal title:The Lancet Oncology, 2023-08, Vol.24, p.925-935
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Genomic characterization of metastatic breast cancers
Author / Creator:Bertucci, François ; Ng, Charlotte K. Y. ; Patsouris, Anne ; Droin, Nathalie ; Piscuoglio, Salvatore ; Carbuccia, Nadine ; Soria, Jean Charles ; Dien, Alicia Tran ; Adnani, Yahia ; Kamal, Maud ; Garnier, Séverine ; Meurice, Guillaume ; Jimenez, Marta ; Dogan, Semih ; Verret, Benjamin ; Chaffanet, Max ; Bachelot, Thomas ; Campone, Mario ; Lefeuvre, Claudia ; Bonnefoi, Herve ; Dalenc, Florence ; Jacquet, Alexandra ; De Filippo, Maria R. ; Babbar, Naveen ; Birnbaum, Daniel ; Filleron, Thomas ; Le Tourneau, Christophe ; André, Fabrice
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2019-05, Vol.569 (7757), p.560-564
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Genomics to select treatment for patients with metastatic breast cancer
Author / Creator:Andre, Fabrice ; Filleron, Thomas ; Kamal, Maud ; Mosele, Fernanda ; Arnedos, Monica ; Dalenc, Florence ; Sablin, Marie-Paule ; Campone, Mario ; Bonnefoi, Hervé ; Lefeuvre-Plesse, Claudia ; Jacot, William ; Coussy, Florence ; Ferrero, Jean-Marc ; Emile, George ; Mouret-Reynier, Marie-Ange ; Thery, Jean-Christophe ; Isambert, Nicolas ; Mege, Alice ; Barthelemy, Philippe ; You, Benoit ; Hajjaji, Nawale ; Lacroix, Ludovic ; Rouleau, Etienne ; Tran-Dien, Alicia ; Boyault, Sandrine ; Attignon, Valery ; Gestraud, Pierre ; Servant, Nicolas ; Le Tourneau, Christophe ; Cherif, Linda Larbi ; Soubeyran, Isabelle ; Montemurro, Filippo ; Morel, Alain ; Lusque, Amelie ; Jimenez, Marta ; Jacquet, Alexandra ; Gonçalves, Anthony ; Bachelot, Thomas ; Bieche, Ivan
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2022-10, Vol.610 (7931), p.343-348
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ArticlesPeer ReviewedFull Text
HDAC Inhibition to Prime Immune Checkpoint Inhibitors
Author / Creator:Borcoman, Edith ; Kamal, Maud ; Marret, Grégoire ; Dupain, Celia ; Castel-Ajgal, Zahra ; Le Tourneau, Christophe
Publisher:Switzerland: MDPI AG
Journal title:Cancers, 2021-12, Vol.14 (1), p.66
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Mutational Profile of Metastatic Breast Cancers: A Retrospective Analysis
Author / Creator:Lefebvre, Celine ; Bachelot, Thomas ; Filleron, Thomas ; Pedrero, Marion ; Campone, Mario ; Soria, Jean-Charles ; Massard, Christophe ; Lévy, Christelle ; Arnedos, Monica ; Lacroix-Triki, Magali ; Garrabey, Julie ; Boursin, Yannick ; Deloger, Marc ; Fu, Yu ; Commo, Frédéric ; Scott, Véronique ; Lacroix, Ludovic ; Dieci, Maria Vittoria ; Kamal, Maud ; Diéras, Véronique ; Gonçalves, Anthony ; Ferrerro, Jean-Marc ; Romieu, Gilles ; Vanlemmens, Laurence ; Mouret Reynier, Marie-Ange ; Théry, Jean-Christophe ; Le Du, Fanny ; Guiu, Séverine ; Dalenc, Florence ; Clapisson, Gilles ; Bonnefoi, Hervé ; Jimenez, Marta ; Le Tourneau, Christophe ; André, Fabrice
Publisher:United States: Public Library of Science
Journal title:PLoS medicine, 2016-12, Vol.13 (12), p.e1002201
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Debio 1143 and high-dose cisplatin chemoradiotherapy in high-risk locoregionally advanced squamous cell carcinoma of the head and neck: a double-blind, multicentre, randomised, phase 2 study
Author / Creator:Sun, Xu-Shan, MD ; Tao, Yungan, MD ; Le Tourneau, Christophe, Prof ; Pointreau, Yoann, MD ; Sire, Christian, MD ; Kaminsky, Marie-Christine, MD ; Coutte, Alexandre, MD ; Alfonsi, Marc, MD ; Boisselier, Pierre, MD ; Martin, Laurent, MD ; Miroir, Jessica, MD ; Ramee, Jean-Francois, MD ; Delord, Jean-Pierre, Prof ; Clatot, Florian, MD ; Rolland, Frederic, MD ; Villa, Julie, MD ; Magne, Nicolas, MD ; Elicin, Olgun, MD ; Gherga, Elisabeta, MD ; Nguyen, France, MD ; Lafond, Cedrick, MD ; Bera, Guillaume, MD ; Calugaru, Valentin, MD ; Geoffrois, Lionnel, MD ; Chauffert, Bruno, MD ; Zubel, Angela, MD ; Zanna, Claudio, MD ; Brienza, Silvano, MD ; Crompton, Philippa, MSc ; Rouits, Elisabeth, PharmD ; Gollmer, Kathrin, PhD ; Szyldergemajn, Sergio, MD ; Bourhis, Jean, Prof
Publisher:London: Elsevier Ltd
Journal title:The lancet oncology, 2020-09, Vol.21 (9), p.1173-1187
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CSF1R inhibition with emactuzumab in locally advanced diffuse-type tenosynovial giant cell tumours of the soft tissue: a dose-escalation and dose-expansion phase 1 study
Author / Creator:Cassier, Philippe A, MD ; Italiano, Antoine, Dr ; Gomez-Roca, Carlos A, MD ; Le Tourneau, Christophe, MD ; Toulmonde, Maud, MD ; Cannarile, Michael A, PhD ; Ries, Carola, PhD ; Brillouet, Anne, BSc ; Müller, Claudia, PhD ; Jegg, Anna-Maria, PhD ; Bröske, Ann-Marie, PhD ; Dembowski, Markus, PhD ; Bray-French, Katharine, PhD ; Freilinger, Christine, PhD ; Meneses-Lorente, Georgina, PhD ; Baehner, Monika, PhD ; Harding, Ross, PhD ; Ratnayake, Jayantha, PhD ; Abiraj, Keelara, PhD ; Gass, Nathalie, PhD ; Noh, Karen, PharmD ; Christen, Randolph D, MD ; Ukarma, Lidia, MD ; Bompas, Emmanuelle, MD ; Delord, Jean-Pierre, Prof ; Blay, Jean-Yves, Prof ; Rüttinger, Dominik, MD
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2015-08, Vol.16 (8), p.949-956
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Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 tr...

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Pembrolizumab in cervical cancer: latest evidence and clinical usefulness

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Comparing programmed death ligand 1 scores for predicting pembrolizumab efficacy in head and neck cancer

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Prognostic value of intratumoral Fusobacterium nucleatum and association with immune-related gene expression in oral squamous cell carcinoma patients

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PD-L1 and ICOSL discriminate human Secretory and Helper dendritic cells in cancer, allergy and autoimmunity

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Assessment of endpoint definitions in recurrent and metastatic mucosal head and neck squamous cell carcinoma trials: Head and Neck Cancer International Group consensus recommendations

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Assessment of endpoint definitions in curative-intent trials for mucosal head and neck squamous cell carcinomas: Head and Neck Cancer International Group consensus recommendations

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Ramucirumab in Combination with Pembrolizumab in Treatment-Naïve Advanced Gastric or GEJ Adenocarcinoma: Safety and Antitumor Activity from the Phase 1a/b JVDF Trial

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Clinical Development of Molecular Targeted Therapy in Head and Neck Squamous Cell Carcinoma

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A transcriptomics approach to expand therapeutic options and optimize clinical trials in oncology

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Hyperprogression under Immunotherapy

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A computational method for prioritizing targeted therapies in precision oncology: performance analysis in the SHIVA01 trial

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Molecular profiling in precision medicine oncology

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Erdafitinib in patients with advanced solid tumours with FGFR alterations (RAGNAR): an international, single-arm, phase 2 study

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Genomic characterization of metastatic breast cancers

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Genomics to select treatment for patients with metastatic breast cancer

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HDAC Inhibition to Prime Immune Checkpoint Inhibitors

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Mutational Profile of Metastatic Breast Cancers: A Retrospective Analysis

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Debio 1143 and high-dose cisplatin chemoradiotherapy in high-risk locoregionally advanced squamous cell carcinoma of the head and neck: a double-blind, multicentre, randomised, phase 2 study

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CSF1R inhibition with emactuzumab in locally advanced diffuse-type tenosynovial giant cell tumours of the soft tissue: a dose-escalation and dose-expansion phase 1 study

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