Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation...
Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation in mature neurons
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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It has been recently described that in embryonic stem cells, the expression of some important developmentally regulated genes is repressed, but poised for fast activation under the appropriate stimuli. In this work we show that
Bdnf
promoters are repressed by Polycomb Complex 2 in mature hippocampal neurons, and basal expression is guaranteed...
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Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation in mature neurons
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TN_cdi_doaj_primary_oai_doaj_org_article_76abe5f97a35480083f5247a8ddfdb84
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_76abe5f97a35480083f5247a8ddfdb84
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms11081
