Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Explor...
Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties
About this item
Full title
Author / Creator
Partridge, Anthony W. , Kaan, Hung Yi Kristal , Juang, Yu-Chi , Sadruddin, Ahmad , Lim, Shuhui , Brown, Christopher J. , Ng, Simon , Thean, Dawn , Ferrer, Fernando , Johannes, Charles , Yuen, Tsz Ying , Kannan, Srinivasaraghavan , Aronica, Pietro , Tan, Yaw Sing , Pradhan, Mohan R. , Verma, Chandra S. , Hochman, Jerome , Chen, Shiying , Wan, Hui , Ha, Sookhee , Sherborne, Brad , Lane, David P. and Sawyer, Tomi K.
Publisher
Switzerland: MDPI AG
Journal title
Language
English
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Publication information
Publisher
Switzerland: MDPI AG
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More information
Scope and Contents
Contents
Stapled α-helical peptides represent an emerging superclass of macrocyclic molecules with drug-like properties, including high-affinity target binding, protease resistance, and membrane permeability. As a model system for probing the chemical space available for optimizing these properties, we focused on dual Mdm2/MdmX antagonist stapled peptides r...
Alternative Titles
Full title
Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties
Authors, Artists and Contributors
Author / Creator
Kaan, Hung Yi Kristal
Juang, Yu-Chi
Sadruddin, Ahmad
Lim, Shuhui
Brown, Christopher J.
Ng, Simon
Thean, Dawn
Ferrer, Fernando
Johannes, Charles
Yuen, Tsz Ying
Kannan, Srinivasaraghavan
Aronica, Pietro
Tan, Yaw Sing
Pradhan, Mohan R.
Verma, Chandra S.
Hochman, Jerome
Chen, Shiying
Wan, Hui
Ha, Sookhee
Sherborne, Brad
Lane, David P.
Sawyer, Tomi K.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_76dd0b05d6584b64a066db0da685651e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_76dd0b05d6584b64a066db0da685651e
Other Identifiers
ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules24122292
