Small molecule inhibition of ATM kinase increases CRISPR-Cas9 1-bp insertion frequency
Small molecule inhibition of ATM kinase increases CRISPR-Cas9 1-bp insertion frequency
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Mutational outcomes following CRISPR-Cas9-nuclease cutting in mammalian cells have recently been shown to be predictable and, in certain cases, skewed toward single genotypes. However, the ability to control these outcomes remains limited, especially for 1-bp insertions, a common and therapeutically relevant class of repair outcomes. Here, through...
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Small molecule inhibition of ATM kinase increases CRISPR-Cas9 1-bp insertion frequency
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TN_cdi_doaj_primary_oai_doaj_org_article_77675116590e4b8aa7e1d10c6a4309b0
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_77675116590e4b8aa7e1d10c6a4309b0
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-25415-8
