A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines
A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Evolution of SARS-CoV-2 alters the antigenicity of the immunodominant spike (S) receptor-binding domain and N-terminal domain, undermining the efficacy of vaccines and antibody therapies. To overcome this challenge, we set out to develop a vaccine focusing antibody responses on the highly conserved but metastable S
2
subunit, which folds as a...
Alternative Titles
Full title
A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_780e43f46b0341b2b056a3f52e383c25
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_780e43f46b0341b2b056a3f52e383c25
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-49656-5
