Structural basis for the biosynthesis of lovastatin
Structural basis for the biosynthesis of lovastatin
About this item
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Author / Creator
Wang, Jialiang , Liang, Jingdan , Chen, Lu , Zhang, Wei , Kong, Liangliang , Peng, Chao , Su, Chen , Tang, Yi , Deng, Zixin and Wang, Zhijun
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Statins are effective cholesterol-lowering drugs. Lovastatin, one of the precursors of statins, is formed from dihydromonacolin L (DML), which is synthesized by lovastatin nonaketide synthase (LovB), with the assistance of a separate
trans
-acting enoyl reductase (LovC). A full DML synthesis comprises 8 polyketide synthetic cycles with about...
Alternative Titles
Full title
Structural basis for the biosynthesis of lovastatin
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_78a7ab70c6d545e6b1e3702fbf340601
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_78a7ab70c6d545e6b1e3702fbf340601
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-21174-8
