Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein
Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Alpha-synuclein (αSyn) is a protein involved in neurodegenerative disorders including Parkinson’s disease. Amyloid formation of αSyn can be modulated by the ‘P1 region’ (residues 36-42). Here, mutational studies of P1 reveal that Y39A and S42A extend the lag-phase of αSyn amyloid formation in vitro and rescue amyloid-associated cytotoxicity in
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Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein
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TN_cdi_doaj_primary_oai_doaj_org_article_795dea3b15b941688aa5f281361c1332
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_795dea3b15b941688aa5f281361c1332
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-32687-1
