Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene exp...
Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles
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Switzerland: Frontiers Media S.A
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English
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Publisher
Switzerland: Frontiers Media S.A
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Enhancer of zeste homolog 2 (Ezh2) is responsible for trimethylation of histone 3 at lysine 27 (H3K27me3), resulting in repression of gene expression. Here, we explore the role of Ezh2 in forebrain GABAergic interneuron development.
We removed
in the MGE by generating
conditional knockout mice. We then characterized changes in MGE-derived...
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Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles
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TN_cdi_doaj_primary_oai_doaj_org_article_79e927d6f7344ce6952eb10177d5b25b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_79e927d6f7344ce6952eb10177d5b25b
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ISSN
1662-5102
E-ISSN
1662-5102
DOI
10.3389/fncel.2024.1334244
