Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physi...
Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site
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Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS) , Lee, Jaeyong , Worrall, Liam J. , Vuckovic, Marija , Rosell, Federico I. , Gentile, Francesco , Ton, Anh-Tien , Caveney, Nathanael A. , Ban, Fuqiang , Cherkasov, Artem , Paetzel, Mark and Strynadka, Natalie C. J.
Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the pathogen that causes the disease COVID-19, produces replicase polyproteins 1a and 1ab that contain, respectively, 11 or 16 nonstructural proteins (nsp). Nsp5 is the main protease (M
pro
) responsible for cleavage at eleven positions along these polyproteins, including at its ow...
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Full title
Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site
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TN_cdi_doaj_primary_oai_doaj_org_article_79fa01c0d7f04a9ab66a27ea9f850fb5
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_79fa01c0d7f04a9ab66a27ea9f850fb5
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-19662-4
