Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to i...
Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection
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Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Acute infection is known to induce rapid expansion of hematopoietic stem cells (HSCs), but the mechanisms supporting this expansion remain incomplete. Using mouse models, we show that inducible CD36 is required for free fatty acid uptake by HSCs during acute infection, allowing the metabolic transition from glycolysis towards β-oxidation. Mechanist...
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Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection
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TN_cdi_doaj_primary_oai_doaj_org_article_7a154f415ae948c1943698ba5d9dbe0d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7a154f415ae948c1943698ba5d9dbe0d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-27460-9
