The Gq signalling pathway inhibits brown and beige adipose tissue
The Gq signalling pathway inhibits brown and beige adipose tissue
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Author / Creator
Klepac, Katarina , Kilić, Ana , Gnad, Thorsten , Brown, Loren M. , Herrmann, Beate , Wilderman, Andrea , Balkow, Aileen , Glöde, Anja , Simon, Katharina , Lidell, Martin E. , Betz, Matthias J. , Enerbäck, Sven , Wess, Jürgen , Freichel, Marc , Blüher, Matthias , König, Gabi , Kostenis, Evi , Insel, Paul A. and Pfeifer, Alexander
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Brown adipose tissue (BAT) dissipates nutritional energy as heat via the uncoupling protein-1 (UCP1) and BAT activity correlates with leanness in human adults. Here we profile G protein-coupled receptors (GPCRs) in brown adipocytes to identify druggable regulators of BAT. Twenty-one per cent of the GPCRs link to the G
q
family, and inhibition...
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Full title
The Gq signalling pathway inhibits brown and beige adipose tissue
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TN_cdi_doaj_primary_oai_doaj_org_article_7a2bc9f5eaee4df68bf0b1b7a219eba3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7a2bc9f5eaee4df68bf0b1b7a219eba3
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms10895
