Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptak...
Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Fosmidomycin is a phosphonic antibiotic which inhibits 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr), the first committed step of the non-mevalonate pathway of isoprenoid biosynthesis. In Mycobacterium tuberculosis Dxr is encoded by Rv2870c, and although the antibiotic has been shown to inhibit the recombinant enzyme 1, mycobacteria are int...
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Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake
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TN_cdi_doaj_primary_oai_doaj_org_article_7c39aeeaa8d94f67942a63b171a6bcba
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7c39aeeaa8d94f67942a63b171a6bcba
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ISSN
1471-2180
E-ISSN
1471-2180
DOI
10.1186/1471-2180-8-78
