Phase I clinical trial repurposing all-trans retinoic acid as a stromal targeting agent for pancreat...
Phase I clinical trial repurposing all-trans retinoic acid as a stromal targeting agent for pancreatic cancer
About this item
Full title
Author / Creator
Kocher, Hemant M. , Basu, Bristi , Froeling, Fieke E. M. , Sarker, Debashis , Slater, Sarah , Carlin, Dominic , deSouza, Nandita M. , De Paepe, Katja N. , Goulart, Michelle R. , Hughes, Christine , Imrali, Ahmet , Roberts, Rhiannon , Pawula, Maria , Houghton, Richard , Lawrence, Cheryl , Yogeswaran, Yathushan , Mousa, Kelly , Coetzee, Carike , Sasieni, Peter , Prendergast, Aaron and Propper, David J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Pre-clinical models have shown that targeting pancreatic stellate cells with all-trans-retinoic-acid (ATRA) reprograms pancreatic stroma to suppress pancreatic ductal adenocarcinoma (PDAC) growth. Here, in a phase Ib, dose escalation and expansion, trial for patients with advanced, unresectable PDAC (n = 27), ATRA is re-purposed as a stromal-target...
Alternative Titles
Full title
Phase I clinical trial repurposing all-trans retinoic acid as a stromal targeting agent for pancreatic cancer
Authors, Artists and Contributors
Author / Creator
Basu, Bristi
Froeling, Fieke E. M.
Sarker, Debashis
Slater, Sarah
Carlin, Dominic
deSouza, Nandita M.
De Paepe, Katja N.
Goulart, Michelle R.
Hughes, Christine
Imrali, Ahmet
Roberts, Rhiannon
Pawula, Maria
Houghton, Richard
Lawrence, Cheryl
Yogeswaran, Yathushan
Mousa, Kelly
Coetzee, Carike
Sasieni, Peter
Prendergast, Aaron
Propper, David J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7c7d3ad82a9e4375ae3a8da492b9ac27
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7c7d3ad82a9e4375ae3a8da492b9ac27
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-18636-w
