CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting the...
CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies
About this item
Full title
Author / Creator
Hwang, Justin H , Arafeh, Rand , Seo, Ji-Heui , Baca, Sylvan C , Ludwig, Megan , Arnoff, Taylor E , Sawyer, Lydia , Richter, Camden , Tape, Sydney , Bergom, Hannah E , McSweeney, Sean , Rennhack, Jonathan P , Klingenberg, Sarah A , Cheung, Alexander T M , Kwon, Jason , So, Jonathan , Kregel, Steven , Van Allen, Eliezer M , Drake, Justin M , Freedman, Matthew L and Hahn, William C
Publisher
England: eLife Sciences Publications Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: eLife Sciences Publications Ltd
Subjects
More information
Scope and Contents
Contents
Metastatic castration-resistant prostate cancers (mCRPCs) are treated with therapies that antagonize the androgen receptor (AR). Nearly all patients develop resistance to AR-targeted therapies (ARTs). Our previous work identified CREB5 as an upregulated target gene in human mCRPC that promoted resistance to all clinically approved ART. The mechanis...
Alternative Titles
Full title
CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies
Authors, Artists and Contributors
Author / Creator
Arafeh, Rand
Seo, Ji-Heui
Baca, Sylvan C
Ludwig, Megan
Arnoff, Taylor E
Sawyer, Lydia
Richter, Camden
Tape, Sydney
Bergom, Hannah E
McSweeney, Sean
Rennhack, Jonathan P
Klingenberg, Sarah A
Cheung, Alexander T M
Kwon, Jason
So, Jonathan
Kregel, Steven
Van Allen, Eliezer M
Drake, Justin M
Freedman, Matthew L
Hahn, William C
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7cd78141b68a418da9a9913b29b5f5c7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7cd78141b68a418da9a9913b29b5f5c7
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.73223
