Phosphatidylserine exposure is required for ADAM17 sheddase function
Phosphatidylserine exposure is required for ADAM17 sheddase function
About this item
Full title
Author / Creator
Sommer, Anselm , Kordowski, Felix , Büch, Joscha , Maretzky, Thorsten , Evers, Astrid , Andrä, Jörg , Düsterhöft, Stefan , Michalek, Matthias , Lorenzen, Inken , Somasundaram, Prasath , Tholey, Andreas , Sönnichsen, Frank D. , Kunzelmann, Karl , Heinbockel, Lena , Nehls, Christian , Gutsmann, Thomas , Grötzinger, Joachim , Bhakdi, Sucharit and Reiss, Karina
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
ADAM17, a prominent member of the ‘Disintegrin and Metalloproteinase’ (ADAM) family, controls vital cellular functions through cleavage of transmembrane substrates. Here we present evidence that surface exposure of phosphatidylserine (PS) is pivotal for ADAM17 to exert sheddase activity. PS exposure is tightly coupled to substrate shedding provoked...
Alternative Titles
Full title
Phosphatidylserine exposure is required for ADAM17 sheddase function
Authors, Artists and Contributors
Author / Creator
Kordowski, Felix
Büch, Joscha
Maretzky, Thorsten
Evers, Astrid
Andrä, Jörg
Düsterhöft, Stefan
Michalek, Matthias
Lorenzen, Inken
Somasundaram, Prasath
Tholey, Andreas
Sönnichsen, Frank D.
Kunzelmann, Karl
Heinbockel, Lena
Nehls, Christian
Gutsmann, Thomas
Grötzinger, Joachim
Bhakdi, Sucharit
Reiss, Karina
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7d870aa38fd548259ffdc80c22adca2f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7d870aa38fd548259ffdc80c22adca2f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms11523
