Nonapoptotic caspase-3 guides C1q-dependent synaptic phagocytosis by microglia
Nonapoptotic caspase-3 guides C1q-dependent synaptic phagocytosis by microglia
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Caspases are known to mediate neuronal apoptosis during brain development. However, here we show that nonapoptotic activation of caspase-3 at presynapses drives microglial synaptic phagocytosis. Real-time observation and spatiotemporal manipulation of synaptic caspase-3 in the newly established, mouse-derived culture system demonstrate that increas...
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Full title
Nonapoptotic caspase-3 guides C1q-dependent synaptic phagocytosis by microglia
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TN_cdi_doaj_primary_oai_doaj_org_article_7e58161ad1354e44bd046e04cb7ae674
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7e58161ad1354e44bd046e04cb7ae674
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-56342-7
