Cofactors facilitate bona fide prion misfolding in vitro but are not necessary for the infectivity o...
Cofactors facilitate bona fide prion misfolding in vitro but are not necessary for the infectivity of recombinant murine prions
About this item
Full title
Author / Creator
Pérez-Castro, Miguel Ángel , Eraña, Hasier , Vidal, Enric , Charco, Jorge M , Lorenzo, Nuria L , Gonçalves-Anjo, Nuno , Galarza-Ahumada, Josu , Díaz-Domínguez, Carlos M , Piñeiro, Patricia , González-Miranda, Ezequiel , Giler, Samanta , Telling, Glenn , Sánchez-Martín, Manuel A , Garrido, Joseba , Geijo, Mariví , Requena, Jesús R and Castilla, Joaquín
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
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More information
Scope and Contents
Contents
Prion diseases, particularly sporadic cases, pose a challenge due to their complex nature and heterogeneity. The underlying mechanism of the spontaneous conversion from PrPC to PrPSc, the hallmark of prion diseases, remains elusive. To shed light on this process and the involvement of cofactors, we have developed an in vitro system that faithfully...
Alternative Titles
Full title
Cofactors facilitate bona fide prion misfolding in vitro but are not necessary for the infectivity of recombinant murine prions
Authors, Artists and Contributors
Author / Creator
Eraña, Hasier
Vidal, Enric
Charco, Jorge M
Lorenzo, Nuria L
Gonçalves-Anjo, Nuno
Galarza-Ahumada, Josu
Díaz-Domínguez, Carlos M
Piñeiro, Patricia
González-Miranda, Ezequiel
Giler, Samanta
Telling, Glenn
Sánchez-Martín, Manuel A
Garrido, Joseba
Geijo, Mariví
Requena, Jesús R
Castilla, Joaquín
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7ecfd6dccd0d41e08f6cfbe9930c714e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7ecfd6dccd0d41e08f6cfbe9930c714e
Other Identifiers
ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1012890
