Preparedness, prevention and control related to zoonotic avian influenza
Preparedness, prevention and control related to zoonotic avian influenza
About this item
Full title
Author / Creator
Alvarez, Julio , Boklund, Anette , Dippel, Sabine , Dórea, Fernanda , Figuerola, Jordi , Herskin, Mette S. , Michel, Virginie , Miranda Chueca, Miguel Ángel , Nannoni, Eleonora , Nielsen, Søren Saxmose , Nonno, Romolo , Riber, Anja B. , Stegeman, Jan Arend , Ståhl, Karl , Thulke, Hans‐Hermann , Tuyttens, Frank , Winckler, Christoph , Brugerolles, Claire , Wolff, Thorsten , Parys, Anna , Lindh, Erika , Latorre‐Margalef, Neus , Rameix Welti, Marie‐Anne , Dürrwald, Ralf , Trebbien, Ramona , Van der Werf, Sylvie , Gisslén, Magnus , Monne, Isabella , Fusaro, Alice , Guinat, Claire , Bortolami, Alessio , Alexakis, Leonidas , Enkirch, Theresa , Svartstrom, Olov , Willgert, Katriina , Baldinelli, Francesca , Preite, Ludovica , Grant, Malin , Broglia, Alessandro , Melidou, Angeliki , EFSA Panel on Animal Health and Animal Welfare (AHAW) and ECDC
Publisher
United States: John Wiley & Sons, Inc
Journal title
Language
English
Formats
Publication information
Publisher
United States: John Wiley & Sons, Inc
Subjects
More information
Scope and Contents
Contents
A risk assessment framework was developed to evaluate the zoonotic potential of avian influenza (AI), focusing on virus mutations linked to phenotypic traits related to mammalian adaptation identified in the literature. Virus sequences were screened for the presence of these mutations and their geographical, temporal and subtype‐specific trends. Spillover events to mammals (including humans) and human seroprevalence studies were also reviewed. Thirty‐four mutations associated with five phenotypic traits (increased receptor specificity, haemagglutinin stability, neuraminidase specificity, enhanced polymerase activity and evasion of innate immunity) were shortlisted. AI viruses (AIVs) carrying multiple adaptive mutations and traits belonged to both low and highly pathogenic subtypes, mainly to A(H9N2), A(H7N9), A(H5N6) and A(H3N8), were sporadic and primarily detected in Asia. In the EU/EEA, H5Nx viruses of clade 2.3.4.4b, which have increased opportunities for evolution due to widespread circulation in birds and occasional cases/outbreaks in mammals, have acquired the highest number of zoonotic traits. Adaptive traits, such as enhanced polymerase activity and immune evasion, were frequently acquired, while receptor‐specific mutations remained rare. Globally, human cases remain rare, with the majority overall due to A(H5N1), A(H5N6), A(H7N9) and A(H9N2) that are among the subtypes that tend to have a higher number of adaptive traits. The main drivers of mammalian adaptation include virus and host characteristics, and external factors increasing AIV exposure of mammals and humans to wild and domestic birds (e.g. human activities and ecological factors). Comprehensive surveillance of AIVs targeting adaptive mutations with whole genome sequencing in animals and humans is essential for early detection of zoonotic AIVs and efficient implementation of control measures. All preparedness, preventive and control measures must be implemented under a One Health framework and tailored to the setting and the epidemiological situation; in particular, enhanced monitoring, biosecurity, genomic surveillance and global collaboration are critical for mitigating the zoonotic risks of AIV.
This publication is linked to the following EFSA Journal article: http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2025.9183/full...
Alternative Titles
Full title
Preparedness, prevention and control related to zoonotic avian influenza
Authors, Artists and Contributors
Author / Creator
Boklund, Anette
Dippel, Sabine
Dórea, Fernanda
Figuerola, Jordi
Herskin, Mette S.
Michel, Virginie
Miranda Chueca, Miguel Ángel
Nannoni, Eleonora
Nielsen, Søren Saxmose
Nonno, Romolo
Riber, Anja B.
Stegeman, Jan Arend
Ståhl, Karl
Thulke, Hans‐Hermann
Tuyttens, Frank
Winckler, Christoph
Brugerolles, Claire
Wolff, Thorsten
Parys, Anna
Lindh, Erika
Latorre‐Margalef, Neus
Rameix Welti, Marie‐Anne
Dürrwald, Ralf
Trebbien, Ramona
Van der Werf, Sylvie
Gisslén, Magnus
Monne, Isabella
Fusaro, Alice
Guinat, Claire
Bortolami, Alessio
Alexakis, Leonidas
Enkirch, Theresa
Svartstrom, Olov
Willgert, Katriina
Baldinelli, Francesca
Preite, Ludovica
Grant, Malin
Broglia, Alessandro
Melidou, Angeliki
EFSA Panel on Animal Health and Animal Welfare (AHAW)
ECDC
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7f1cc173073c4fe59d7503d29a096c58
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7f1cc173073c4fe59d7503d29a096c58
Other Identifiers
ISSN
1831-4732
E-ISSN
1831-4732
DOI
10.2903/j.efsa.2025.9191