Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-functi...
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
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England: eLife Sciences Publications Ltd
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English
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England: eLife Sciences Publications Ltd
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Genetic variations in the myeloid immune receptor TREM2 are linked to several neurodegenerative diseases. To determine how TREM2 variants contribute to these diseases, we performed structural and functional studies of wild-type and variant proteins. Our 3.1 Å TREM2 crystal structure revealed that mutations found in Nasu-Hakola disease are buried wh...
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Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
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TN_cdi_doaj_primary_oai_doaj_org_article_7f535c3839034845a7ec354cf07f2651
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7f535c3839034845a7ec354cf07f2651
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.20391
