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Transfer learning enables prediction of CYP2D6 haplotype function

Transfer learning enables prediction of CYP2D6 haplotype function

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7fff972297404355b40a56134eab5609

Transfer learning enables prediction of CYP2D6 haplotype function

About this item

Full title

Transfer learning enables prediction of CYP2D6 haplotype function

Publisher

United States: Public Library of Science

Journal title

PLoS computational biology, 2020-11, Vol.16 (11), p.e1008399

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Cytochrome P450 2D6 (
CYP2D6
) is a highly polymorphic gene whose protein product metabolizes more than 20% of clinically used drugs. Genetic variations in
CYP2D6
are responsible for interindividual heterogeneity in drug response that can lead to drug toxicity and ineffective treatment, making
CYP2D6
one of the most important phar...

Alternative Titles

Full title

Transfer learning enables prediction of CYP2D6 haplotype function

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_7fff972297404355b40a56134eab5609

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7fff972297404355b40a56134eab5609

Other Identifiers

ISSN

1553-7358,1553-734X

E-ISSN

1553-7358

DOI

10.1371/journal.pcbi.1008399

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