Substrate-Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype
Substrate-Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype
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Switzerland: Frontiers Research Foundation
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Language
English
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Switzerland: Frontiers Research Foundation
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Contents
Intramembrane-cleaving proteases (I-CLiPs) catalyze the hydrolysis of peptide bonds within the transmembrane regions of membrane protein substrates, releasing bioactive fragments that play roles in many physiological and pathological processes. Based on their catalytic mechanism and nucleophile, I-CLiPs are classified into metallo, serine, aspartyl...
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Full title
Substrate-Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype
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TN_cdi_doaj_primary_oai_doaj_org_article_80276726071c49adaf14fdbc590dc305
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_80276726071c49adaf14fdbc590dc305
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ISSN
1662-5099
E-ISSN
1662-5099
DOI
10.3389/fnmol.2020.00065
