Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain
Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Phosphorylation of MDM2 by ATM upon DNA damage is an important mechanism for deregulating MDM2, thereby leading to p53 activation. ATM phosphorylates multiple residues near the RING domain of MDM2, but the underlying molecular basis for deregulation remains elusive. Here we show that Ser429 phosphorylation selectively enhances the ubiquitin ligase...
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Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain
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TN_cdi_doaj_primary_oai_doaj_org_article_80e8bf383dda460bb88d16b6b1cd6555
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_80e8bf383dda460bb88d16b6b1cd6555
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-15783-y
