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ArticlesPeer ReviewedFull Text
Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death
Author / Creator:Cheung, Eric C ; Ludwig, Robert L ; Vousden, Karen H
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-12, Vol.109 (50), p.20491-20496
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ArticlesPeer ReviewedFull Text
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy
Author / Creator:Tajan, Mylène ; Hennequart, Marc ; Cheung, Eric C. ; Zani, Fabio ; Hock, Andreas K. ; Legrave, Nathalie ; Maddocks, Oliver D. K. ; Ridgway, Rachel A. ; Athineos, Dimitris ; Suárez-Bonnet, Alejandro ; Ludwig, Robert L. ; Novellasdemunt, Laura ; Angelis, Nikolaos ; Li, Vivian S. W. ; Vlachogiannis, Georgios ; Valeri, Nicola ; Mainolfi, Nello ; Suri, Vipin ; Friedman, Adam ; Manfredi, Mark ; Blyth, Karen ; Sansom, Owen J. ; Vousden, Karen H.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-01, Vol.12 (1), p.366-366, Article 366
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Modulation of intracellular ROS levels by TIGAR controls autophagy
Author / Creator:Bensaad, Karim ; Cheung, Eric C ; Vousden, Karen H
Publisher:Chichester, UK: John Wiley & Sons, Ltd
Journal title:The EMBO journal, 2009-10, Vol.28 (19), p.3015-3026
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ArticlesPeer ReviewedFull Text
Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation
Author / Creator:Jones, Nicholas ; Blagih, Julianna ; Zani, Fabio ; Rees, April ; Hill, David G. ; Jenkins, Benjamin J. ; Bull, Caroline J. ; Moreira, Diana ; Bantan, Azari I. M. ; Cronin, James G. ; Avancini, Daniele ; Jones, Gareth W. ; Finlay, David K. ; Vousden, Karen H. ; Vincent, Emma E. ; Thornton, Catherine A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-02, Vol.12 (1), p.1209-13, Article 1209
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Serine is a natural ligand and allosteric activator of pyruvate kinase M2
Author / Creator:Chaneton, Barbara ; Hillmann, Petra ; Zheng, Liang ; Martin, Agnès C. L. ; Maddocks, Oliver D. K. ; Chokkathukalam, Achuthanunni ; Coyle, Joseph E. ; Jankevics, Andris ; Holding, Finn P. ; Vousden, Karen H. ; Frezza, Christian ; O’Reilly, Marc ; Gottlieb, Eyal
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2012-11, Vol.491 (7424), p.458-462
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Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl
Author / Creator:Dou, Hao ; Buetow, Lori ; Hock, Andreas ; Sibbet, Gary J ; Vousden, Karen H ; Huang, Danny T
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2012-02, Vol.19 (2), p.184-192
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The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cells
Author / Creator:Hennequart, Marc ; Labuschagne, Christiaan F. ; Tajan, Mylène ; Pilley, Steven E. ; Cheung, Eric C. ; Legrave, Nathalie M. ; Driscoll, Paul C. ; Vousden, Karen H.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-10, Vol.12 (1), p.6176-6176, Article 6176
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Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer
Author / Creator:Tucci, Paola ; Agostini, Massimiliano ; Grespi, Francesca ; Markert, Elke K ; Terrinoni, Alessandro ; Vousden, Karen H ; Muller, Patricia A. J ; Dötsch, Volker ; Kehrloesser, Sebastian ; Sayan, Berna S ; Giaccone, Giuseppe ; Lowe, Scott W ; Takahashi, Nozomi ; Vandenabeele, Peter ; Knight, Richard A ; Levine, Arnold J ; Melino, Gerry
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-09, Vol.109 (38), p.15312-15317
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ArticlesPeer ReviewedFull Text
Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity
Author / Creator:Nomura, Koji ; Klejnot, Marta ; Kowalczyk, Dominika ; Hock, Andreas K ; Sibbet, Gary J ; Vousden, Karen H ; Huang, Danny T
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2017-07, Vol.24 (7), p.578-587
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Serine and one-carbon metabolism in cancer
Author / Creator:Yang, Ming ; Vousden, Karen H.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Cancer, 2016-10, Vol.16 (10), p.650-662
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PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma
Author / Creator:D’Avola, Annalisa ; Legrave, Nathalie ; Tajan, Mylène ; Chakravarty, Probir ; Shearer, Ryan L. ; King, Hamish W. ; Kluckova, Katarina ; Cheung, Eric C. ; Clear, Andrew J. ; Gunawan, Arief S. ; Zhang, Lingling ; James, Louisa K. ; MacRae, James I. ; Gribben, John G. ; Calado, Dinis P. ; Vousden, Karen H. ; Riches, John C.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2022-05, Vol.132 (9), p.1-17
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Alternative fuel--another role for p53 in the regulation of metabolism
Author / Creator:Vousden, Karen H
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-04, Vol.107 (16), p.7117-7118
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ArticlesPeer ReviewedFull Text
Regulation of p53 stability and function by the deubiquitinating enzyme USP42
Author / Creator:Hock, Andreas K ; Vigneron, Arnaud M ; Carter, Stephanie ; Ludwig, Robert L ; Vousden, Karen H
Publisher:Chichester, UK: John Wiley & Sons, Ltd
Journal title:The EMBO journal, 2011-12, Vol.30 (24), p.4921-4930
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The role of ROS in tumour development and progression
Author / Creator:Cheung, Eric C. ; Vousden, Karen H.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Cancer, 2022-05, Vol.22 (5), p.280-297
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Proliferation, cell cycle and apoptosis in cancer
Author / Creator:Evan, Gerard I. ; Vousden, Karen H.
Publisher:England: Nature Publishing Group
Journal title:Nature (London), 2001-05, Vol.411 (6835), p.342-348
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Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain
Author / Creator:Magnussen, Helge M. ; Ahmed, Syed F. ; Sibbet, Gary. J. ; Hristova, Ventzislava A. ; Nomura, Koji ; Hock, Andreas K. ; Archibald, Lewis J. ; Jamieson, Andrew G. ; Fushman, David ; Vousden, Karen H. ; Weissman, Allan M. ; Huang, Danny T.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-04, Vol.11 (1), p.2094-2094, Article 2094
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p53 in survival, death and metabolic health: a lifeguard with a licence to kill
Author / Creator:Kruiswijk, Flore ; Labuschagne, Christiaan F. ; Vousden, Karen H.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Molecular cell biology, 2015-07, Vol.16 (7), p.393-405
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p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival
Author / Creator:Croft, Daniel R ; Crighton, Diane ; Samuel, Michael S ; Lourenco, Filipe C ; Munro, June ; Wood, Jenifer ; Bensaad, Karim ; Vousden, Karen H ; Sansom, Owen J ; Ryan, Kevin M ; Olson, Michael F
Publisher:London: Nature Publishing Group UK
Journal title:Cell research, 2011-04, Vol.21 (4), p.666-682
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Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo
Author / Creator:Hock, Andreas K. ; Cheung, Eric C. ; Humpton, Timothy J. ; Monteverde, Tiziana ; Paulus-Hock, Viola ; Lee, Pearl ; McGhee, Ewan ; Scopelliti, Alessandro ; Murphy, Daniel J. ; Strathdee, Douglas ; Blyth, Karen ; Vousden, Karen H.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-05, Vol.7 (1), p.1837-9, Article 1837
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PHD1 regulates p53‐mediated colorectal cancer chemoresistance
Author / Creator:Deschoemaeker, Sofie ; Di Conza, Giusy ; Lilla, Sergio ; Martín‐Pérez, Rosa ; Mennerich, Daniela ; Boon, Lise ; Hendrikx, Stefanie ; Maddocks, Oliver DK ; Marx, Christian ; Radhakrishnan, Praveen ; Prenen, Hans ; Schneider, Martin ; Myllyharju, Johanna ; Kietzmann, Thomas ; Vousden, Karen H ; Zanivan, Sara ; Mazzone, Massimiliano
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2015-10, Vol.7 (10), p.1350-1365
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Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death

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Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy

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Modulation of intracellular ROS levels by TIGAR controls autophagy

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Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation

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Serine is a natural ligand and allosteric activator of pyruvate kinase M2

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Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl

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The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cells

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Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

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Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity

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Serine and one-carbon metabolism in cancer

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PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma

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Alternative fuel--another role for p53 in the regulation of metabolism

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Regulation of p53 stability and function by the deubiquitinating enzyme USP42

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The role of ROS in tumour development and progression

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Proliferation, cell cycle and apoptosis in cancer

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Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain

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p53 in survival, death and metabolic health: a lifeguard with a licence to kill

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p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival

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Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo

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PHD1 regulates p53‐mediated colorectal cancer chemoresistance

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