Venetoclax resistance in acute lymphoblastic leukemia is characterized by increased mitochondrial ac...
Venetoclax resistance in acute lymphoblastic leukemia is characterized by increased mitochondrial activity and can be overcome by co-targeting oxidative phosphorylation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Deregulated apoptosis signaling is characteristic for many cancers and contributes to leukemogenesis and treatment failure in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Apoptosis is controlled by different pro- and anti-apoptotic molecules. Inhibition of anti-apoptotic molecules like B-cell lymphoma 2 (BCL-2) has been developed as the...
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Venetoclax resistance in acute lymphoblastic leukemia is characterized by increased mitochondrial activity and can be overcome by co-targeting oxidative phosphorylation
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TN_cdi_doaj_primary_oai_doaj_org_article_81d58ab860b9478bbf43ea3ace525546
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_81d58ab860b9478bbf43ea3ace525546
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-024-06864-7
